Related Experiment Video
Updated: Jun 1, 2026

09:45
Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
2-(Phenyl-carbonothio-ylsulfan-yl)acetic acid
Summary
This study explores a novel compound for controlling polymerization reactions. It details the compound
Area of Science:
- Polymer Chemistry
- Crystallography
Background:
- Controlling polymerization reactions is crucial for developing new materials.
- Chain transfer agents play a key role in regulating polymer properties.
Purpose of the Study:
- To investigate the potential of a specific organic compound (C9H8O2S2) as a chain transfer agent.
- To elucidate the crystal structure and intermolecular interactions of the compound.
Main Methods:
- X-ray crystallography was used to determine the molecular and crystal structure.
- Analysis of hydrogen bonding and other intermolecular forces.
Main Results:
- The compound C9H8O2S2 forms dimers through moderate O-H⋯O hydrogen bonds.
- These dimers assemble into sheets via C-H⋯O interactions, creating specific ring structures (R4(2)(12) and R2(2)(8)).
- No intermolecular interactions involving sulfur atoms were observed.
Conclusions:
- The compound C9H8O2S2 exhibits potential as a chain transfer agent in polymerization.
- Its crystal structure reveals specific hydrogen bonding and sheet formation, influencing its behavior.
Related Concept Videos
Preparation and Reactions of Sulfides
Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones
Acetals are formed by reacting two equivalents of alcohol with carbonyl compounds like aldehydes or ketones. Acetals are unaffected by bases, nucleophiles, oxidizing agents, and reducing agents. They serve as protecting groups for aldehydes and ketones. Acetals can be easily formed and also easily removed via mild acid hydrolysis.
In the presence of multiple functional groups, when selective reduction of one group over the other is desired, groups like aldehydes and ketones that form acetals...
In the presence of multiple functional groups, when selective reduction of one group over the other is desired, groups like aldehydes and ketones that form acetals...
Preparation and Reactions of Thiols
Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.
Phase II Reactions: Sulfation and Conjugation with α-Amino Acids
Sulfation and α-amino acid conjugation are two critical biotransformation reactions in drug metabolism. Sulfation, a phase II biotransformation reaction, involves adding a polar sulfate group to a drug, enhancing its water solubility and promoting excretion. This process can either co-occur with or occur independently of glucuronidation. Nonmicrosomal sulfotransferase enzymes catalyze the process. The reaction involves 3'-phosphoadenosine-5'-phosphosulfate or PAPS coenzyme activation, sulfur...
Structure and Nomenclature of Thiols and Sulfides
Thiols and sulfides are sulfur analogs of alcohols and ethers, respectively, where the sulfur atom takes the place of the oxygen atom. Thus, thiols are generally represented as RSH, where R is an alkyl substituent and —SH is the functional group. On the other hand, in sulfides, the central sulfur atom is bonded to two hydrocarbon groups on either side. Depending upon the type of group, sulfides can be either symmetrical or asymmetrical. Both thiols and sulfides display a bent geometry, similar...
Acid Halides to Esters: Alcoholysis
Alcoholysis is a nucleophilic acyl substitution reaction in which an alcohol functions as a nucleophile. Acid halides react with alcohol to produce esters. The mechanism proceeds in three steps:

