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Updated: Jun 1, 2026

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
1,5-Bis-[1-(2-hy-droxy-phen-yl)ethyl-idene]carbonohydrazide dimethyl-formamide monosolvate
1College of Chemistry and Chemical Engineering, Liaocheng University, Shandong 252059, People's Republic of China.
Abstract:
In the title compound, C(17)H(18)N(4)O(3)·C(3)H(7)NO, the main disubstituted urea and solvate mol-ecules are linked by pairs of N-H⋯O hydrogen bonds. In the main mol-ecules, the benzene rings form a dihedral angle of 15.59 (13)° a;nd two intra-molecular O-H⋯N hydrogen bonds influence the mol-ecular conformation. In the crystal structure, weak inter-molecular C-H⋯O inter-actions link the hydrogen-bonded pairs into chains along the b axis. The chains associate via C-H⋯π inter-actions.
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Preparation of Amides
The DCC-promoted synthesis of amides begins with the protonation of DCC by carboxylic acid. The protonation makes it a better acceptor. Next, the addition of carboxylate to the protonated carbodiimide gives a reactive acylating agent.
Subsequently, the amine acts as a nucleophile that attacks the acylating agent to form a tetrahedral intermediate. In the...

