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Updated: Jun 1, 2026
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Published on: October 24, 2017
1-Benzyl-idene-4-ethyl-thio-semicarbazide
Summary
Researchers synthesized a novel compound, C(10)H(13)N(3)S, using 4-ethyl-thio-semicarbazide and benzaldehyde. Structural analysis revealed specific molecular arrangements and hydrogen bonding critical for its crystal formation.
Area of Science:
- Organic Chemistry
- Crystallography
- Supramolecular Chemistry
Background:
- Thio-semicarbazide derivatives are known for diverse biological activities.
- Benzaldehyde is a common precursor in organic synthesis.
- Understanding molecular interactions is key to designing new materials.
Purpose of the Study:
- To synthesize and characterize a novel thio-semicarbazide derivative.
- To investigate the crystal structure and intermolecular interactions of the synthesized compound.
- To explore the role of hydrogen bonding in crystal packing.
Main Methods:
- Chemical synthesis via condensation reaction.
- Single-crystal X-ray diffraction for structural determination.
- Analysis of hydrogen bonding networks and crystal lattice.
Main Results:
- Successful synthesis of the target compound C(10)H(13)N(3)S.
- The crystal structure exhibits a small dihedral angle (8.96°) between the benzene ring and the thio-urea moiety.
- An intramolecular N-H⋯N hydrogen bond forms an S(5) ring, and intermolecular N-H⋯S hydrogen bonds create R(2)(2)(8) loops in the crystal.
Conclusions:
- The synthesized compound possesses a unique molecular conformation influenced by intramolecular hydrogen bonding.
- Intermolecular hydrogen bonding plays a significant role in the self-assembly and crystal architecture.
- This study provides insights into the structure-property relationships of thio-semicarbazide derivatives.
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