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Updated: Jun 1, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
(E)-N'-[4-(Dimethyl-amino)-benzyl-idene]-4-hy-droxy-benzohydrazide hemihydrate
1School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan 528453, People's Republic of China.
Abstract:
In the title compound, C(16)H(17)N(3)O(2)·0.5H(2)O, the two hydrazide mol-ecules are approximately planar: the dihedral angles between the two substituted benzene rings are 7.7 (2) and 4.2 (2)°. Both hydrazone mol-ecules exist in a trans geometry with respect to their methyl-idene units. In the crystal, the water mol-ecule lies between the two organic mol-ecules and makes bifurcated O-H⋯(N,O) hydrogen bonds to both of them. The hydrazide mol-ecules form N-H⋯O and O-H⋯O hydrogen bonds, resulting in a three-dimensional network.
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