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Updated: Jun 1, 2026

Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish

Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish

Published on: May 5, 2021

Polythia-zide.

Thomas Gelbrich¹, Mairi F Haddow, Ulrich J Griesser

¹Institute of Pharmacy, University of Innsbruck, Innrain 52, 6020 Innsbruck, Austria.

Acta Crystallographica. Section E, Structure Reports Online

|May 19, 2011

Summary

This summary is machine-generated.

The crystal structure of a benzothiadiazine derivative reveals a 2D network formed by hydrogen bonds. Molecular interactions and the thiadiazine ring conformation were detailed.

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A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

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Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish

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Published on: May 5, 2021

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

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Published on: February 28, 2013

Area of Science:

Crystallography
Chemical Structure Analysis
Organic Chemistry

Background:

Benzothiadiazine derivatives are important in medicinal chemistry.
Understanding the crystal structure provides insights into molecular interactions and properties.

Purpose of the Study:

To determine and analyze the crystal structure of 6-chloro-2-methyl-3-{[(2,2,2-trifluoro-eth-yl)sulfan-yl]meth-yl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sul-f-on-amide 1,1-diox-ide.
To elucidate the intermolecular interactions and conformational aspects of the molecule in the solid state.

Main Methods:

Single-crystal X-ray diffraction was employed to determine the crystal structure.
Analysis of hydrogen bonding (N-H⋯O, C-H⋯O) and conformational analysis of the thiadiazine ring.

Main Results:

The compound forms a two-dimensional network of hydrogen-bonded molecules.
The crystal structure exhibits N-H⋯O and C-H⋯O hydrogen bonds, with NH and NH(2) groups as donors and sulfonyl O atoms as acceptors.
The thiadiazine ring adopts an envelope conformation with a methyl substituent in an axial position.

Conclusions:

The crystal structure provides a detailed understanding of the solid-state organization and intermolecular forces.
The conformational analysis offers insights into the molecule's spatial arrangement, relevant for structure-activity relationship studies.