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Updated: Jun 1, 2026

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
(R)-2-Benzyl-4-methyl-pentyl (R)-2-meth-oxy-2-(1-naphth-yl)propionate
Abstract:
The relative configuration of the alcohol component in the title ester, C(27)H(32)O(3), has been assigned as (R) from the known configuration of (R)-(-)-2-meth-oxy-2-(1-naphth-yl)propionic acid [(R)-MαNP acid]. In the crystal structure, the C atom of the methyl group of the MαNP acid lies in the extended plane of the naphthyl ring system [methyl C atom deviates from plane by 0.211 (2) Å; r.m.s. deviation of fitted atoms = 0.0187 Å] and a weak intra-molecular C-H⋯O hydrogen bond links the naphthyl ring system and the meth-oxy group. These structural properties are similar to those of most MαNP acid esters.
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