5-Meth-oxy-1-(3,4,5-trimethoxy-phen-yl)-1H-indole
Thomas Blake Monroe1, Casey Rimland, Yasamin Moazami
1Department of Chemistry, The University of North Carolina at Charlotte, 9201 University City Blvd, Charlotte, NC 28223, USA.
Summary
Researchers synthesized a novel indole derivative, C(18)H(19)NO(4), with potential anti-mitotic activity. Molecular analysis revealed specific ring interactions crucial for its crystalline structure and potential biological function.
Area of Science:
- Medicinal Chemistry
- Crystallography
- Organic Synthesis
Background:
- Indole derivatives are recognized for diverse biological activities.
- Anti-mitotic agents are critical in cancer therapy.
- Understanding molecular structure aids drug design.
Purpose of the Study:
- To synthesize a novel indole derivative, C(18)H(19)NO(4).
- To investigate its potential anti-mitotic properties.
- To elucidate the crystal structure and intermolecular interactions.
Main Methods:
- Organic synthesis of the title compound.
- Single-crystal X-ray diffraction analysis.
- Analysis of dihedral angles and intermolecular interactions (C-H⋯π).
Main Results:
- Successful synthesis of the indole derivative C(18)H(19)NO(4).
- The dihedral angle between indole and trimethoxy-phenyl rings is 45.35°.
- Identified arene C-H⋯arene-π interactions of 3.035 Å in the crystal structure.
Conclusions:
- The synthesized compound is a novel indole derivative.
- The determined crystal structure provides insights into its molecular conformation.
- The identified interactions may be relevant to its potential anti-mitotic activity.
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