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Related Experiment Video

Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Published on: January 19, 2016

N-(4-Nitro-pheneth-yl)formamide.

Li-Ping He, Xiao-Ming Yang, Dao-Lin Pang

    Acta Crystallographica. Section E, Structure Reports Online
    |May 19, 2011
    PubMed
    Summary
    This summary is machine-generated.

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    A novel synthesis of a nitro-phenethylamine derivative was achieved through direct N-formylation. The resulting crystal structure reveals molecules linked by hydrogen bonds, forming chains along the a axis.

    Area of Science:

    • Organic Chemistry
    • Crystallography

    Background:

    • 4-nitro-phenethylamine hydrochloride is a precursor with potential applications.
    • Direct N-formylation offers a potentially efficient synthetic route.

    Purpose of the Study:

    • To synthesize a specific nitro-phenethylamine derivative.
    • To characterize the crystal structure of the synthesized compound.

    Main Methods:

    • Direct N-formylation of 4-nitro-phenethylamine hydrochloride using formic acid and sodium formate.
    • Single crystal X-ray diffraction to determine molecular and crystal structure.

    Main Results:

    • Successful synthesis of the target compound C(9)H(10)N(2)O(3) without catalyst or solvent.
    • Crystal structure analysis confirmed intermolecular N-H⋯O hydrogen bonds linking molecules into chains parallel to the a axis.

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    Last Updated: Jun 1, 2026

    Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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    Published on: January 19, 2016

    Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
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    Conclusions:

    • Direct N-formylation is an effective method for synthesizing this nitro-phenethylamine derivative.
    • The crystal packing is dominated by intermolecular hydrogen bonding, influencing the solid-state structure.