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Related Concept Videos

Diazonium Group Substitution: –OH and –H01:19

Diazonium Group Substitution: –OH and –H

Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.
Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
Carboxylic Acids to Methylesters: Alkylation using Diazomethane01:33

Carboxylic Acids to Methylesters: Alkylation using Diazomethane

Carboxylic acids react with diazomethane in an ether solvent via alkylation at the carboxylate oxygen atom to give methyl esters of the corresponding acid with excellent yields.
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH301:11

ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3

All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
Nomenclature of Aryl and Heterocyclic Amines01:10

Nomenclature of Aryl and Heterocyclic Amines

The simplest aromatic amine is phenylamine, which contains an –NH2 functionality directly attached to an aromatic ring. The name aniline is designated for this skeleton. As shown in Figure 1, the common names of the functionalized anilines involve prefixes ortho-, meta-, and para- to indicate the substitution position. Different functionalized aniline derivatives also have notable trivial names.
Nomenclature of Primary Amines01:17

Nomenclature of Primary Amines

Primary, secondary, and tertiary amines are compounds consisting of one, two, and three alkyl groups connected to the amino group (–NH2), respectively. As depicted in Figure 1, the common name of the primary amines is obtained by adding the suffix -amine to the alkyl substituent attached to the amino group as the corresponding alkylamine.

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Related Experiment Video

Updated: Jun 1, 2026

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
07:30

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

1-(Morpholino-meth-yl)indoline-2,3-dione.

Ying Tang, Jie Zhang, Yanqing Miao

    Acta Crystallographica. Section E, Structure Reports Online
    |May 19, 2011
    PubMed
    Summary

    The crystal structure of a novel compound, C(13)H(14)N(2)O(3), reveals a specific molecular arrangement. Intermolecular hydrogen bonds stabilize the crystal lattice, providing insights into molecular interactions.

    Area of Science:

    • Crystallography
    • Organic Chemistry
    • Molecular Structure

    Background:

    • Understanding the three-dimensional arrangement of molecules is crucial in chemistry.
    • Crystal structure analysis provides detailed information about molecular geometry and intermolecular forces.

    Purpose of the Study:

    • To determine and describe the crystal structure of the compound C(13)H(14)N(2)O(3).
    • To elucidate the conformation of the morpholine ring and the position of the (2,3-dioxoindolin-1-yl)methyl group.
    • To identify the types of intermolecular interactions stabilizing the crystal.

    Main Methods:

    • Single-crystal X-ray diffraction was employed to analyze the crystal structure.
    • Conformational analysis was performed on the determined molecular geometry.

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    Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
    09:10

    Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities

    Published on: May 27, 2015

    Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
    14:11

    Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach

    Published on: June 10, 2021

  • Identification of intermolecular interactions, such as hydrogen bonds, was carried out.

    • Main Results:

    • The morpholine ring in the title compound adopts a chair conformation.
    • The (2,3-dioxoindolin-1-yl)methyl substituent is found in an equatorial position.
    • The crystal structure is stabilized by intermolecular C-H⋯O hydrogen bonds.

    Conclusions:

    • The study provides a detailed structural characterization of C(13)H(14)N(2)O(3).
    • The observed conformation and hydrogen bonding patterns offer insights into the solid-state behavior of this molecule.
    • This structural data can be valuable for further research in medicinal chemistry or materials science.