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Updated: Jun 1, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
3-[(3S)-3-Ethyl-1-methyl-azepan-3-yl]phenyl N-(4-fluoro-phen-yl)carbamate
Jian Sun1, Qiong Xie, Zhui-Bai Qiu
1Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, People's Republic of China.
Abstract:
The asymmetric unit of the title compound, C(22)H(27)FN(2)O(2), a (-)-S-meptazinol derivative, contains two mol-ecules. The azepane ring adopts a similar twist chair form in both mol-ecules, while the dihedral angles between the two benzene rings are 88.17 (14) and 89.93 (14)° in the two mol-ecules. The absolute configuration of the mol-ecule was determined from the synthetic starting material. The crystal structure is stabilized by classical inter-molecular N-H⋯O hydrogen bonds.
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