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Updated: Jun 1, 2026
08:43
Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
3-Fluoro-4-(4-hy-droxy-phen-oxy)benzonitrile
Summary
This study synthesized a novel compound, C(13)H(8)FNO(2), using specific precursors. The crystal structure reveals molecules linked by hydrogen bonds, forming unique zigzag chains.
Area of Science:
- Organic Chemistry
- Crystallography
- Materials Science
Background:
- The synthesis of novel organic compounds is crucial for developing new materials.
- Understanding molecular interactions and crystal packing is key to predicting material properties.
Purpose of the Study:
- To synthesize and characterize a new organic compound with the molecular formula C(13)H(8)FNO(2).
- To investigate the crystal structure and intermolecular interactions of the synthesized compound.
Main Methods:
- Chemical synthesis involving 3,4-difluoro-benzonitrile and hydro-quinone.
- X-ray diffraction analysis to determine the crystal structure.
- Analysis of hydrogen bonding and molecular conformation.
Main Results:
- Successful synthesis of the target compound C(13)H(8)FNO(2).
- Determination of a dihedral angle of 70.9° between the aromatic rings.
- Identification of O-H⋯N hydrogen bonds facilitating the formation of zigzag chains in the crystal lattice.
Conclusions:
- The synthesized compound exhibits a specific molecular conformation and crystal packing.
- Hydrogen bonding plays a significant role in the self-assembly of these molecules into extended chains.
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