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Updated: Jun 1, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
N-(4-Chloro-phen-yl)-2-(8-quinol-yloxy)acetamide monohydrate
Abstract:
In the title compound, C(17)H(13)ClN(2)O(2)·H(2)O, the dihedral angle between the quinoline ring system and the benzene ring is 13.0 (1)°. An intra-molecular N-H⋯O hydrogen bond may influence the mol-ecular conformation. In the crystal structure, acetamide mol-ecules are linked to water mol-ecules via inter-molecular O-H⋯ N and N-H⋯O hydrogen bonds and in turn linked into chains along [010] via O-H⋯O hydrogen bonds.
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