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Updated: Jun 1, 2026

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

Published on: January 1, 2016

Xyloccensin L.

Gang Feng, Jing Zhang, Jun Li

Acta Crystallographica. Section E, Structure Reports Online

|May 19, 2011

Summary

This summary is machine-generated.

This study reports the first X-ray crystal structure of xyloccensin L, a unique limonoid. The research details its complex molecular structure and stabilization through intramolecular hydrogen bonding.

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Synthesis and Assay of Vibrio Quorum Sensing Inhibitors

Synthesis and Assay of Vibrio Quorum Sensing Inhibitors

Published on: May 31, 2024

Area of Science:

Natural Product Chemistry
Structural Chemistry
Crystallography

Background:

Limonoids are a diverse class of terpenoids found in nature.
Structural elucidation of complex natural products is crucial for understanding their properties and potential applications.

Purpose of the Study:

To determine the X-ray crystal structure of xyloccensin L.
To characterize the unique structural features of this limonoid, including its C1-C29 oxygen bridge.

Main Methods:

X-ray crystallography was employed to determine the three-dimensional structure.
Analysis of bond lengths, bond angles, and conformations was performed.

Main Results:

The first X-ray crystal structure of a limonoid with a C1-C29 oxygen bridge was successfully obtained.
Specific ring conformations were identified: boat for fused pyran and cyclohexane rings, half-chair for another cyclohexane and the d-lactone ring.
Intramolecular O-H⋯O hydrogen bonding was observed, contributing to molecular stability.

Conclusions:

The study provides unprecedented structural insights into xyloccensin L.
The findings contribute to the understanding of limonoid structural diversity and chemical bonding.
The detailed structural information can serve as a basis for further research into the biological activity and synthesis of this compound.