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Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
5-tert-Butyl-2-hy-droxy-3-(2-thien-yl)benzaldehyde
Yanwei Wang1, Zhenzhen Qiu, Hongze Liang
1Faculty of Materials Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang 315211, People's Republic of China.
Abstract:
In the crystal structure of the title compound, C(15)H(16)O(2)S, the thio-phene ring is essentially planar (r.m.s. deviation = 0.006 Å for all non-H atoms) and roughly coplanar with the benzene ring, the dihedral angle between the mean planes of the rings being 4.35 (8)°. An intra-molecular O-H⋯O hydrogen bond is observed between the OH group and the aldehyde O atom.
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