Related Experiment Video
Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
4-Chloro-N-[(E)-(3,4-dimeth-oxy-phen-yl)methyl-idene]aniline
This study reveals two distinct molecular conformations within the crystal structure of C(15)H(14)ClNO(2). These molecules interact through hydrogen bonds and weak π-interactions, offering insights into crystal packing.
Area of Science:
- Crystallography
- Organic Chemistry
- Molecular Structure
Background:
- Understanding molecular conformation is crucial in predicting chemical properties and interactions.
- Crystal engineering relies on characterizing intermolecular forces to design novel materials.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C(15)H(14)ClNO(2).
- To analyze the conformational diversity and intermolecular interactions within the crystal lattice.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of dihedral angles and hydrogen bonding networks was performed.
Main Results:
- The asymmetric unit contains two molecules with significantly different conformations.
- Dihedral angles between the 4-chloro-aniline and 3,4-dimethoxy-phenyl moieties are 19.68°(7) and 45.54°(4).
- Molecules are linked by C-H⋯O hydrogen bonds and weak C-H⋯π interactions.
Conclusions:
- The study highlights conformational isomerism within the crystal structure of C(15)H(14)ClNO(2).
- The observed intermolecular interactions provide a basis for understanding crystal packing and potential solid-state properties.
More Related Videos
07:30A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
Published on: January 21, 2020
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
Related Concept Videos
Nomenclature of Aryl and Heterocyclic Amines
Diazonium Group Substitution: –OH and –H
Nomenclature of Primary Amines
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Preparation of Acid Anhydrides
The carboxylate ion acts as a nucleophile that attacks the carbonyl carbon of the acid chloride to form a tetrahedral intermediate. Subsequently, the re-formation of the carbonyl group with the loss of the chloride ion as a leaving group leads to the formation of an acid...