Related Experiment Video
Updated: Jun 1, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
2-Hy-droxy-N-(3-nitro-phen-yl)benzamide
Abstract:
In the crystal structure of title compound, C(13)H(10)N(2)O(4), as expected, the nitro- and hy-droxy-substituted benzene rings are planar with r. m. s. deviations of 0.0037 and 0.0014 Å, respectively, but are twisted slightly relative to each other, making a dihedral angle of 12.23 (7)°. The nitro group is only slightly twisted [by 2.71 (16)°] with respect to its parent ring. An intra-molecular N-H⋯O hydrogen bond forms an S(6) ring motif. Inter-molecular N-H⋯O and O-H⋯O hydrogen bonds build up sheets parallel to the ab plane. Futhermore, weak π-π inter-actions [centroid-centroid distances = 3.7150 (8) 3.7342 (6) and 3.9421 (8) Å] between the rings yield a three-dimensional network.
More Related Videos
Related Concept Videos
Diazonium Group Substitution: –OH and –H
Electrophilic Aromatic Substitution: Nitration of Benzene
Nucleophilic Aromatic Substitution: Elimination–Addition
Hydrolysis of Chlorobenzene to Phenol: Dow Process
meta-Directing Deactivators: –NO2, –CN, –CHO, –⁠CO2R, –COR, –CO2H
Antihypertensive Drugs: Thiazide-Class Diuretics

