Related Experiment Video
Updated: Jun 1, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
3,5-Bis(4-hy-droxy-phen-yl)-4H-1,2,4-triazol-4-amine monohydrate
Abstract:
The triazole ring in the title compound, C(14)H(12)N(4)O(2)·H(2)O, makes dihedral angles of 36.9 (1) and 37.3 (1)° with the two benzene rings. Each hy-droxy group is a hydrogen-bond donor to a two-coordinate N atom of an adjacent mol-ecule; these O-H⋯N hydrogen bonds generate a layer parallel to the ab plane. Adjacent layers are linked by N--H⋯O and O(water)-H⋯O hydrogen bonds into a three-dimensional network.
Related Concept Videos
Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview
Diazonium Group Substitution: –OH and –H
Preparation of Amines: Reductive Amination of Aldehydes and Ketones

