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Updated: Jun 1, 2026

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
2-Benzyl-sulfanyl-3-(2,2,2-trifluoro-ethoxy)pyridine
Zhi-Qiang Feng1, Xiao-Li Yang, Yuan-Feng Ye
1College of Materials Engineering, Jinling Institute of Technology, No. 99 Hongjing Street, Nanjing, Nanjing 211169, People's Republic of China.
Abstract:
The title compound, C(14)H(12)F(3)NOS, was synthesized by the reaction of 2-chloro-3-(2,2,2-trifluoro-eth-oxy)pyridine and phenyl-methane-thiol. The dihedral angle between the aromatic rings is 76.7 (2)°. In the crystal structure, weak aromatic π-π stacking between inversion-related pairs of pyridine rings [centroid-to-centroid separation = 3.776 (2) Å] may help to establish the packing.
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