Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...
Acidity and Basicity of Alcohols and Phenols02:36

Acidity and Basicity of Alcohols and Phenols

Like water, alcohols are weak acids and bases. This is attributed to the polarization of the O–H bond making the hydrogen partially positive. Moreover, the electron pairs on the oxygen atom of alcohol make it both basic and nucleophilic. Protonation of an alcohol converts hydroxide, a poor leaving group, into water—a good one. The two acid–base equilibria corresponding to ethanol are depicted below.
Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance.

Nature communications·2020
Same author

Carbon doped Fe<sub>3</sub>O<sub>4</sub> peroxidase-like nanozyme for mitigating the membrane fouling by NOM at neutral pH.

Water research·2020
Same author

Rapid Monitoring Approach for Microplastics Using Portable Pyrolysis-Mass Spectrometry.

Analytical chemistry·2020
Same author

Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance.

Nature communications·2020
Same author

Power calculation for the general two-sample Mendelian randomization analysis.

Genetic epidemiology·2020
Same author

A Facile Grinding Method for the Synthesis of 3D Ag Metal-Organic Frameworks (MOFs) Containing Ag<sub>6</sub> Mo<sub>7</sub> O<sub>24</sub> for High-Performance Supercapacitors.

Chemistry (Weinheim an der Bergstrasse, Germany)·2020

Related Experiment Video

Updated: Jun 1, 2026

Determination of 45 Pesticides in Avocado Varieties by the QuEChERS Method and Gas Chromatography-Tandem Mass Spectrometry
05:20

Determination of 45 Pesticides in Avocado Varieties by the QuEChERS Method and Gas Chromatography-Tandem Mass Spectrometry

Published on: December 8, 2023

10H-Phenothia-zine 5-oxide.

Rui-Fang Jin1, Kai Yu, Shi-Yao Yang

  • 1Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online
|May 19, 2011
PubMed
Summary

This study details the crystal structure of a novel organic compound, C(12)H(9)NOS. Key findings include sulfoxide oxygen atom disorder and significant intermolecular interactions like hydrogen bonds and pi-pi contacts.

More Related Videos

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes
10:26

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes

Published on: January 16, 2015

Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies
09:37

Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies

Published on: January 19, 2022

Related Experiment Videos

Last Updated: Jun 1, 2026

Determination of 45 Pesticides in Avocado Varieties by the QuEChERS Method and Gas Chromatography-Tandem Mass Spectrometry
05:20

Determination of 45 Pesticides in Avocado Varieties by the QuEChERS Method and Gas Chromatography-Tandem Mass Spectrometry

Published on: December 8, 2023

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes
10:26

Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes

Published on: January 16, 2015

Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies
09:37

Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies

Published on: January 19, 2022

Area of Science:

  • Crystallography
  • Organic Chemistry
  • Materials Science

Background:

  • Understanding the crystal structure of organic compounds is crucial for predicting their physical and chemical properties.
  • Supramolecular interactions play a significant role in the self-assembly and properties of crystalline materials.

Purpose of the Study:

  • To elucidate the detailed crystal structure of the title compound, C(12)H(9)NOS.
  • To investigate the types and significance of intermolecular interactions present in the crystal lattice.

Main Methods:

  • Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
  • Analysis of the crystal structure involved identifying bond lengths, bond angles, dihedral angles, and intermolecular contacts.

Main Results:

  • The crystal structure revealed a disordered sulfoxide oxygen atom over two sites (0.907(4) and 0.093(4) occupancy).
  • A dihedral angle of 18.40(14)° was observed between the two aromatic rings.
  • Intermolecular N-H⋯O hydrogen bonds and π-π contacts (centroid-centroid distances of 3.9096(16) and 4.1423(16) Å) were identified, indicating significant supramolecular assembly.

Conclusions:

  • The crystal structure of C(12)H(9)NOS is characterized by sulfoxide disorder and diverse supramolecular interactions.
  • These interactions, including hydrogen bonding and π-π stacking, dictate the packing and stability of the crystal structure.
  • The findings contribute to the understanding of structure-property relationships in organic crystalline materials.