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Updated: Jun 1, 2026

Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
(2E,6E)-2,6-Bis(2-fluoro-5-meth-oxy-benzyl-idene)cyclo-hexan-1-one
Linfeng Chen1, Li Zhang, Zhe Wang
1School of Pharmacy, Wenzhou Medical College, Wenzhou, Zhejiang Province 325035, People's Republic of China.
This study details the crystal structure of a novel curcumin derivative, C(22)H(20)F(2)O(3). The research reveals specific molecular alignments and dihedral angles within its two independent molecules, highlighting its unique structural characteristics.
Area of Science:
- Crystallography
- Organic Chemistry
- Molecular Structure
Background:
- Curcumin derivatives are of interest due to their diverse biological activities.
- Understanding the precise molecular geometry of synthetic analogs is crucial for structure-activity relationship studies.
Purpose of the Study:
- To elucidate the crystal structure of a novel difluorinated curcumin derivative, C(22)H(20)F(2)O(3).
- To analyze the spatial arrangement and conformational properties of the molecule in the solid state.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the crystal structure.
- Analysis of crystallographic data included bond lengths, bond angles, and dihedral angles.
Main Results:
- The compound C(22)H(20)F(2)O(3) crystallized with two independent molecules in the asymmetric unit.
- Detailed analysis revealed specific dihedral angles between the phenyl rings and the central enone system, with values ranging from 45.69° to 54.00°.
- Both molecules exhibited E configurations around the central olefinic bonds.
Conclusions:
- The crystal structure provides precise geometric information about this fluorinated curcumin analog.
- The observed molecular conformations offer insights into the potential for specific intermolecular interactions and biological targeting.
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