Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Existence of structural, electronic and magnetic correlations in Sm<sub>2</sub>NiMnO<sub>6</sub>double perovskite.

Journal of physics. Condensed matter : an Institute of Physics journal·2025
Same author

Temperature dependent structural properties of Mn<sub>1.90</sub>M<sub>0.10</sub>O<sub>3</sub>(M = Cr and Fe).

Journal of physics. Condensed matter : an Institute of Physics journal·2023
Same author

Comparative study of the short-range structure of α-V<sub>2</sub>O<sub>5</sub>, α-TeO<sub>2</sub> and xV<sub>2</sub>O<sub>5</sub>-(100 - x)TeO<sub>2</sub> glasses using X-ray diffraction, Rietveld analysis and reverse Monte Carlo simulations.

Acta crystallographica Section B, Structural science, crystal engineering and materials·2023
Same author

Promising Role of Silk-Based Biomaterials for Ocular-Based Drug Delivery and Tissue Engineering.

Polymers·2022
Same author

Silk Fibroin as an Efficient Biomaterial for Drug Delivery, Gene Therapy, and Wound Healing.

International journal of molecular sciences·2022
Same author

Global Effect of COVID-19 Pandemic on Cancer Patients and its Treatment: A Systematic Review.

Clinical complementary medicine and pharmacology·2022

Related Experiment Video

Updated: Jun 1, 2026

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
06:10

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

Published on: March 30, 2020

Microencapsulation: A promising technique for controlled drug delivery.

M N Singh1, K S Y Hemant, M Ram

  • 1Department of Pharmaceutics, JSS College of Pharmacy, SS Nagar, Mysore, Karnataka-570015, India.

Research in Pharmaceutical Sciences
|May 19, 2011
PubMed
Summary

Microparticles offer superior drug delivery by protecting agents, controlling release rates from hours to months, and enabling easy administration. These advancements enhance drug targeting and therapeutic efficacy for improved patient outcomes.

Keywords:
Controlled releaseDrug delivery systemsMicrocapsulesMicroencapsulation

More Related Videos

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

Related Experiment Videos

Last Updated: Jun 1, 2026

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
06:10

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

Published on: March 30, 2020

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

Area of Science:

  • Pharmaceutics
  • Materials Science
  • Biomedical Engineering

Background:

  • Microparticles offer significant advantages as drug delivery systems, including protection against degradation and controlled release over extended periods.
  • They provide a promising avenue for developing advanced oral controlled release systems, addressing challenges in drug localization within the gastrointestinal tract.

Purpose of the Study:

  • To provide an overview of the general aspects and recent advances in drug-loaded microparticles.
  • To explore the potential of microparticles in enhancing drug delivery efficiency, optimizing release profiles, and improving drug targeting.
  • To review fundamental aspects of microcapsules for drug delivery applications.

Main Methods:

  • Literature review of general aspects and recent advances in drug-loaded microparticles.
  • Discussion of controlled release mechanisms and targeting strategies.
  • Analysis of microparticulate systems for oral drug delivery.

Main Results:

  • Microparticles facilitate controlled drug release, ranging from hours to months, with pre-programmed profiles matching therapeutic needs.
  • They offer effective protection for encapsulated active agents against degradation.
  • Microparticulate systems present a viable solution for oral controlled release, overcoming limitations of traditional systems.

Conclusions:

  • Drug-loaded microparticles represent a significant advancement in drug delivery systems, offering enhanced protection, controlled release, and improved targeting.
  • Their design can optimize therapeutic efficacy and patient compliance, particularly for oral administration.
  • Further exploration of microcapsule technology holds promise for innovative medical treatments.