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Updated: Jun 1, 2026
Experimental Metastasis Assay
Published on: August 24, 2010
The 67 kD laminin-receptor in high and low metastatic melanoma cell lines
1CHINESE UNIV HONG KONG,DEPT ANAT,SHATIN,NT,HONG KONG. CHINESE UNIV HONG KONG,DEPT PHYSIOL,SHATIN,NT,HONG KONG. CHINESE UNIV HONG KONG,DEPT ANAT & CELLULAR BIOL,SHATIN,NT,HONG KONG. SHANTOU UNIV MED COLL,DEPT HISTOL & EMBRYOL,SHANTOU,PEOPLES R CHINA. BEIJING MED UNIV,DEPT PATHOL,BEIJING 100083,PEOPLES R CHINA.
Abstract:
Four melanoma cell lines with different metastatic potential were used to study the expression of 67 kD laminin receptor (LnR) gene by traditional immunohistochemistry and polymerase chain reaction techniques. Intensive labeling of LnR protein was found in cells with high metastatic potential. Also, the result from PCR and RT-PCR proved the correlation between LnR gene and metastatic potential of melanoma cells in addition to other cell types from previous studies. It is, thus, suggested that the expression of LnR gene can be used as an early marker for the malignancy of melanoma cells.
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