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Updated: Jun 1, 2026
07:18
Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
Published on: June 13, 2019
Cystosarcoma phyllodes of the breast
T Kobayashi1, H Asakawa, Y Komoike
1OSAKA UNIV,SCH MED,DEPT INTERNAL MED 2,SUITA,OSAKA 565,JAPAN.
Oncology Reports
|May 19, 2011
Summary
Cystosarcoma phyllodes (CP) recurrence is linked to tumor size and histology, not patient age. Larger, borderline, or malignant tumors require close follow-up after breast-conserving surgery.
Area of Science:
- Oncology
- Surgical Pathology
- Breast Cancer Research
Background:
- Cystosarcoma phyllodes (CP) is a rare breast tumor with variable behavior.
- Accurate prediction of recurrence and malignant potential is crucial for patient management.
Purpose of the Study:
- To investigate factors influencing recurrence and malignant histopathology in cystosarcoma phyllodes.
- To identify prognostic indicators for disease-free interval in CP patients.
Main Methods:
- Retrospective analysis of 49 patients diagnosed with cystosarcoma phyllodes.
- Histopathological grading (benign, borderline, malignant) and tumor size measurement.
- Multivariate analysis to assess independent prognostic factors for recurrence.
Main Results:
- Tumor size (≥4 cm) and borderline/malignant histology were significant predictors of recurrence.
- Age was not a significant factor for predicting recurrence or malignant histopathology.
- Histopathological diagnosis correlated with clinical outcomes, with 6 recurrences observed.
Conclusions:
- Tumor size and histology are independent prognostic factors for disease-free interval in cystosarcoma phyllodes.
- Breast-conserving surgery with wide margins is recommended.
- Close follow-up is essential for patients with larger tumors or malignant/borderline histopathology.
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