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Updated: Jun 1, 2026

Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis
Published on: November 8, 2024
Expression of epidermal growth factor and its receptor in gestational trophoblastic diseases
M John1, T Rajalekshmy, B Nair
1REG CANC CTR,TRIVANDRUM 695011,KERALA,INDIA. SREE AVITTOM THIRUNAL HOSP,TRIVANDRUM 695011,KERALA,INDIA. DOCTORS DIAGNOST RES CTR,TRIVANDRUM 695011,KERALA,INDIA. MED COLL HOSP TRIVANDRUM,COLL MED,TRIVANDRUM 695011,KERALA,INDIA. INST WOUND RES,GAINESVILLE,FL 32610.
Abstract:
Gestational trophoblastic diseases (GTD) is an abnormal condition of the placenta, the incidence of which is very high in the State of Kerala, India. Placentae of normal (50) and molar pregnancy (122) including 52 showing persistent disease were used for the study. EGFR and EGF expression was analyzed by immunohistochemistry using monoclonal antibodies. EGF receptors were quantitated using the I-125 EGF-binding assay and that of EGF was quantitated using isotope labelled antibody to EGF. Tumours with histological diagnosis of invasive moles and choriocarcinoma showed very strong binding of both EGF and EGFR. The present observations also suggest the possibility of presence of mutated EGF receptors in persistent trophoblastic disease.
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