Related Experiment Video
Updated: Jun 1, 2026

Purification of Ubiquitinated p53 Proteins from Mammalian Cells
Published on: March 21, 2022
The expression of MDM2 and p53 protein breast carcinoma
Abstract:
We studied the expression of MDM2 protein and p53 protein in 67 cases of the breast carcinoma. The result demonstrated no significant relationship between the MDM2 protein expression and any of the clinicopathological parameters except for the estrogen receptor status (p=0.033). Furthermore, in p53 protein negative cases, there was a significant relationship between MDM2 protein expression and the ER status (p=0.027). This study showed the expression of ER to be associated with MDM2 protein in p53 protein negative breast carcinoma. These results thus suggested that an investigation of both p53 and MDM2 gene alteration revealed precise information regarding breast carcinoma.
Related Concept Videos
Abnormal Proliferation
Master Transcription Regulators
