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Updated: Jun 1, 2026
07:35
Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
Microsatellite instability in Japanese colorectal carcinoma
H Nakashima1, M Mori, K Mimori
1KYUSHU UNIV,MED INST BIOREGULAT,DEPT SURG,BEPPU,OITA 874,JAPAN. KYUSHU UNIV,FAC MED,DEPT SURG 2,FUKUOKA 812,JAPAN. OITA PREFECTURAL HOSP,DEPT SURG,OITA,JAPAN.
Oncology Reports
|May 19, 2011
Summary
Microsatellite instability (MSI) was found in 24% of Japanese colorectal cancer (CRC) cases. MSI-positive CRC showed less lymph node metastasis, suggesting a potentially less aggressive cancer behavior.
Area of Science:
- Oncology
- Molecular Biology
- Gastroenterology
Background:
- Microsatellite instability (MSI) is increasingly recognized for its role in cancer development.
- Understanding the clinicopathologic significance of MSI in colorectal carcinoma (CRC) is crucial for patient management.
Purpose of the Study:
- To investigate the incidence and clinicopathologic significance of MSI in a Japanese cohort of colorectal carcinoma (CRC) patients.
- To determine the association between MSI and clinicopathologic features, specifically lymph node metastasis.
Main Methods:
- Utilized polymerase chain reaction (PCR)-based methods to detect MSI.
- Analyzed 54 Japanese cases of colorectal carcinoma (CRC).
Main Results:
- The incidence of MSI in the studied CRC cases was 24% (13 out of 54).
- A significant tendency for lower lymph node metastasis was observed in CRC cases with MSI (P<0.05).
- Survival and prognosis data were unavailable due to short follow-up periods.
Conclusions:
- The incidence of MSI in Japanese CRC is 24%.
- MSI in colorectal carcinoma may be associated with a less malignant clinical behavior, indicated by reduced lymph node metastasis.
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