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Updated: Jun 1, 2026

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
Bcl-2 and p53 expressions in large-cell lymphoma
1KYUNG HEE UNIV,SCH MED,DEPT INTERNAL MED,SEOUL 130702,SOUTH KOREA. KYUNG HEE UNIV,SCH MED,DEPT PREVENT MED,SEOUL 130702,SOUTH KOREA. KEIMYUNG UNIV,SCH MED,DEPT PATHOL,TAEGU,SOUTH KOREA. UNIV TEXAS,MD ANDERSON CANC CTR,DEPT PATHOL,HOUSTON,TX 77030.
Abstract:
Bcl-2 and p53 regulate apoptosis in a see-saw fashion and are expressed abnormally in a variety of malignant tumors. We investigated the frequency and prognostic significance of both bcl-2 and p53 expression in 31 large-cell lymphomas. Immunoreaction of bcl-2 and p53 was found in 74% (23/31) and 65% (20/31) of large-cell lymphomas, respectively. Overall survival was not significantly associated with immunoreactivity for either bcl-2 or p53. Frequent association with both p53 and bcl-2 in large-cell lymphomas confirms the existence of a multistep genetic deregulation in lymphomagenesis, but their clinical significance remains to be elucidated in a larger study.
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