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Published on: October 3, 2010
Solitary intracranial plasmacytomas
B Mihaljevic1, M Colovic, D Cvetkovic
1UNIV BELGRADE,SCH MED,INST HEMATOL,YU-11000 BELGRADE,YUGOSLAVIA. UNIV BELGRADE,SCH MED,INST PATHOL,YU-11000 BELGRADE,YUGOSLAVIA.
Oncology Reports
|May 19, 2011
Summary
We report two rare cases of intracranial plasmacytoma, a type of plasma cell tumor, in women who experienced long-term survival. Surgical removal and radiation therapy led to complete remission in both patients.
Area of Science:
- Neurology
- Oncology
- Pathology
Background:
- Extramedullary plasmacytoma is a rare plasma cell neoplasm.
- Intracranial plasmacytomas are exceptionally uncommon, with limited data on long-term outcomes.
Purpose of the Study:
- To present two unique cases of solitary cerebral plasmacytomas.
- To highlight long-term survival and successful treatment in these rare intracranial tumors.
Main Methods:
- Case presentation of two patients with intracranial plasmacytoma.
- Histological, histochemical, and immunohistochemical analyses of tumor tissues.
- Diagnostic workup to rule out multiple myeloma.
- Surgical resection followed by craniospinal radiation therapy.
Main Results:
- Two female patients (42 and 25 years old) with solitary intracranial plasmacytomas (temporal and parietal lobes).
- Tumor tissues confirmed monoclonal plasma cells.
- Complete remission achieved and sustained for 7.5 and 5.5 years post-treatment.
- Patients received 40 Gy whole cranium and 20 Gy focal radiation therapy.
Conclusions:
- Solitary cerebral plasmacytomas can present with favorable long-term outcomes.
- Multimodal treatment including surgery and radiation is effective.
- Thorough investigation is crucial to differentiate from multiple myeloma.
