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Updated: Jun 1, 2026

Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
Fertility-preserving treatment for advanced malignant germ cell tumors of the ovary
H Nishimura1, K Imamura, T Maruuchi
1KANSAI MED UNIV,DEPT PATHOL 2,MORIGUCHI,OSAKA 570,JAPAN.
Abstract:
We retrospectively studied 26 patients with stage Ic or greater malignant germ cell tumors of the ovary. Sixteen of the 26 underwent fertility-preserving treatment and 10 underwent total hystero-oophorectomy. There were 3 deaths in each group, but none among the stage Ic cases. The survival curves for stage II to IV disease did not significantly differ in the two groups. Seven patients in the fertility-preserving group were married, and had children. All patients in the hystero-oophorectomy group remained single except for one who was married before surgery. These results suggest that fertility-preserving treatment should be offered even in advanced cases.
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