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Related Experiment Video

Updated: Jun 1, 2026

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

A variable neovascularization threshold in tumor-bearing mice.

O Bustuoabad, P Digianni, R Ruggiero

    Oncology Reports
    |May 19, 2011
    PubMed
    Summary

    Tumor growth influences the body's angiogenic response, creating a variable threshold for new blood vessel formation. This threshold increases with tumor progression, affecting the development of secondary tumors.

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    Area of Science:

    • Oncology
    • Immunology
    • Vascular Biology

    Background:

    • Solid tumor development relies on angiogenesis (new blood vessel formation).
    • Tumor-induced neovascularization can paradoxically lead to dormant secondary tumor implants.
    • The tumor-host relationship involves complex interactions influencing angiogenic responses.

    Purpose of the Study:

    • To investigate the variable threshold of angiogenic response in the tumor-host relationship.
    • To determine how tumor growth affects the host's capacity to generate new blood vessels.
    • To explore the role of stimulus intensity and tumor progression on angiogenesis.

    Main Methods:

    • Inducing host angiogenic responses via intradermal injections of varying numbers of polymorphonuclear cells (PEM), semiallogeneic lymphocytes, or irradiated tumor cells.

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    Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
    08:19

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    Published on: July 20, 2019

    The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye
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    Published on: August 16, 2014

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  • Comparing capillary neoformation in tumor-bearing mice versus normal controls at different stages of tumor growth (9, 12, and 15 days).
  • Assessing angiogenic responses to progressively higher stimuli at specific tumor growth days.

    • Main Results:

    • Tumor growth progressively inhibited capillary neoformation induced by low angiogenic stimuli.
    • At higher stimuli, angiogenic response was enhanced in 9-day tumor-bearing mice, normal in 12-day, and inhibited in 15-day.
    • Tumor-bearing mice showed enhanced angiogenic responses compared to controls when subjected to progressively higher stimuli on days 9, 12, or 15.
    • Similar results in PEM-induced granulomas suggest a counter-inflammatory phenomenon.

    Conclusions:

    • An angiogenic threshold exists that increases with tumor growth.
    • The host's angiogenic response depends on whether the stimulus intensity surpasses this dynamic threshold.
    • Tumor progression modulates the angiogenic capacity, impacting potential secondary tumor development.