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Lymphomatous meningitis in immunocompetent patients
1UNIV CALIF SAN DIEGO,DEPT NURSING,LA JOLLA,CA 92093.
Oncology Reports
|May 19, 2011
Summary
This study investigated combined therapy for lymphomatous meningitis in non-Hodgkin
Area of Science:
- Neuro-oncology
- Hematology
- Clinical Medicine
Background:
- Lymphomatous meningitis (LM) is increasingly diagnosed due to improved lymphoma treatments and prolonged survival.
- LM presents with diverse neurological symptoms, impacting quality of life.
Purpose of the Study:
- To evaluate the efficacy and toxicity of combined modality therapy for non-AIDS related lymphomatous meningitis.
- To assess treatment responses and survival outcomes in patients with LM.
Main Methods:
- Prospective study of 22 patients with metastatic non-AIDS related non-Hodgkin's lymphoma and LM.
- Treatment included radiotherapy and sequential intraventricular chemotherapy (methotrexate, cytarabine, thio-TEPA).
- Radiographic and cytologic evaluations assessed central nervous system (CNS) disease extent and treatment response.
Main Results:
- Cytologic responses observed in 73% to first-line, 58% to second-line, and 40% to third-line chemotherapy.
- Common toxicities included aseptic meningitis (64%) and hematologic issues (55%).
- Median survival was 10 months; 64% died of systemic disease, 14% of progressive LM.
Conclusions:
- Combined modality therapy can palliate lymphomatous meningitis in non-AIDS related non-Hodgkin's lymphoma.
- Despite aggressive chemotherapy, including dose-intensive regimens, the therapy remains non-curative.
- Further research is needed to improve curative strategies for LM.
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