Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Degenerative Disc Disease ll: Pathophysiology

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

Chronic Bowel Disorders: Introduction

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

Degenerative Disc Disease I: Introduction

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...

Rheumatic Heart Disease I: Introduction

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

Structural Joints: Cartilaginous Joints

Structural Joints: Cartilaginous Joints

As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

New treatment options in ankylosing spondylitis: a role for anti-TNFalpha therapy.

Annals of the rheumatic diseases·2002

Same author

[Current status of therapeutic approaches in spondyloarthropathies].

Zeitschrift fur Rheumatologie·2002

Same author

Effective treatment of early rheumatoid arthritis with a combination of methotrexate, prednisolone and cyclosporin.

Rheumatology (Oxford, England)·2002

Same author

Brain areas specific for attentional load in a motion-tracking task.

Journal of cognitive neuroscience·2002

Same author

Infliximab treatment of severe ankylosing spondylitis: one-year followup.

Arthritis and rheumatism·2002

Same author

Magnetic resonance elastography: a method for the noninvasive and spatially resolved observation of phase transitions in gels.

Journal of the American Chemical Society·2001

Same journal

Der Internist·2024

Same journal

Der Internist·2024

Same journal

Der Internist·2024

Same journal

Der Internist·2024

Same journal

Der Internist·2024

Same journal

Der Internist·2024

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

[Spondyloarthritides].

J Braun¹, M Rudwaleit, J Sieper

¹Rheumazentrum Ruhrgebiet, Ruhr-Universität Bochum, Landgrafenstrasse 15, Herne, Germany. J.Braun@rheumazentrum-ruhrgebiet.de

|May 19, 2011

Summary

This summary is machine-generated.

Spondyloarthritides are inflammatory rheumatic diseases like ankylosing spondylitis. Early diagnosis is improving with genetic testing (HLA-B27) and advanced imaging, aiding patient management.

More Related Videos

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

Related Experiment Videos

Last Updated: Jun 1, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

Area of Science:

Rheumatology
Immunogenetics
Inflammatory Diseases

Context:

Spondyloarthritides (SpA) encompass a group of inflammatory rheumatic disorders.
Key subtypes include ankylosing spondylitis, psoriatic spondyloarthritis, and spondylarthritis associated with inflammatory bowel disease.
Common symptoms include inflammatory back pain, peripheral arthritis, and enthesitis.

Purpose:

To provide an overview of spondyloarthritides, including their classification, clinical manifestations, and genetic factors.
To highlight advancements in early diagnostic methods for SpA.
To reference recent updates in classification criteria and management guidelines.

Summary:

SpA shares clinical and genetic links, with ankylosing spondylitis being the most prominent subtype.
Extra-articular manifestations such as eye, skin, and intestinal involvement are characteristic.
The human leukocyte antigen B27 (HLA-B27) is a significant genetic marker, particularly in ankylosing spondylitis.

Impact:

Improved understanding of SpA heterogeneity and shared features.
Enhanced early detection capabilities through HLA-B27 testing and MRI.
Facilitation of evidence-based clinical practice with new classification criteria and management recommendations.