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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Vaccinations01:51

Vaccinations

Overview
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Humoral Immune Responses01:36

Humoral Immune Responses

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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

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Related Experiment Video

Updated: Jun 1, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

[Sublingual immunotherapy. Where are we now?].

H Lee1, T Zuberbier, M Worm

  • 1Allergie-Centrum-Charité, Klinik für Dermatologie, Venerologie und Allergologie, Charité-Universitätsmedizin Berlin, Berlin.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|May 19, 2011
PubMed
Summary

Specific immunotherapy (SIT) effectively treats IgE-mediated allergic diseases like allergic rhinitis and asthma. The sublingual-swallow method (SLIT) offers a well-tolerated alternative to subcutaneous injections, benefiting adults and children.

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Intralymphatic Immunotherapy and Vaccination in Mice
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Area of Science:

  • Immunology
  • Allergology

Context:

  • Allergic diseases affect 20-30% of the global population, significantly impacting quality of life and incurring economic costs.
  • Individuals aged 20-40 years experience higher prevalence (over 40%) and symptom-related impairments.

Purpose:

  • To review the efficacy, safety, and health economic impact of specific immunotherapy (SIT) for IgE-mediated allergic diseases.
  • To highlight the established role of SIT in managing allergic rhinitis, rhinoconjunctivitis, and allergic asthma.

Summary:

  • Specific immunotherapy (SIT) has been a trusted treatment for over a century, with robust evidence supporting its effectiveness and safety.
  • Subcutaneous immunotherapy (SCIT) was the initial method, but newer routes like sublingual-swallow immunotherapy (SLIT) have emerged.
  • SLIT has demonstrated efficacy and tolerability in large-scale studies, particularly for grass pollen allergies, offering an alternative for adults and children.

Impact:

  • SIT provides a positive health economic impact by reducing disease burden and associated costs.
  • The development of alternative administration routes like SLIT enhances treatment accessibility and patient adherence.
  • Effective management of allergic diseases through SIT improves patient well-being, sleep, and work/school performance.