Squamous cell carcinoma in the larynx in a 7-year-child

Squamous cell carcinoma (SCC) involving the larynx in childhood is very rare, especially in the ages younger than 10 years. Most of the reported cases are transformed from the recurrent respiratory papillomatosis (RRP) with human papilloma virus (HPV) infection. Due to the RRP long course, the rarity and the unspecific symptoms of the cancer, they usually are diagnosed at late stages. Controversy exists regarding the causes and the treatments of these kinds of diseases. Here, we reviewed the related reports and presented a case of 7-year-old boy who had an advanced well-differentiated SCC of the larynx which transformed from RRP with HPV genotyping test negative. The patient underwent only the resection of involved tissues and no other treatments. Except for hoarseness in his voice, the boy is going well and has had an uneventful course of 10 years following operative treatment.