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Related Experiment Video

Updated: Jun 1, 2026

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration
13:17

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Published on: May 26, 2014

Small, stable, and monodispersed bubbles encapsulated with biopolymers.

Jai Il Park1, Ethan Tumarkin, Eugenia Kumacheva

  • 1Department of Chemistry, University of Toronto, 80 Saint George Street, Toronto, ON M5S 3H6, Canada.

Macromolecular Rapid Communications
|May 19, 2011
PubMed
Summary

Researchers developed a microfluidic method to create stable, small protein-polysaccharide bubbles. These bubbles, less than 10 micrometers, remain intact for up to a month.

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Area of Science:

  • Biomaterials Engineering
  • Microfluidics
  • Colloid Science

Background:

  • Producing stable, small-sized bubbles for applications is challenging.
  • Existing methods often result in broad size distributions or poor long-term stability.

Purpose of the Study:

  • To report a novel microfluidic approach for generating highly stable, monodisperse microbubbles.
  • To encapsulate these microbubbles with a protein-polysaccharide shell.

Main Methods:

  • Microfluidic generation of bubbles using CO2 and low-solubility gases in a lysozyme and sodium alginate solution.
  • Utilizing CO2 dissolution-induced pH changes to trigger sequential shell deposition.
  • Protein (lysozyme) adsorption at the gas-water interface followed by polysaccharide (alginate) complexation.

Related Experiment Videos

Last Updated: Jun 1, 2026

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration
13:17

Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Published on: May 26, 2014

Main Results:

  • Successfully produced microbubbles with sizes below 10 micrometers.
  • Achieved a narrow size distribution for the generated bubbles.
  • Demonstrated long-term stability of the encapsulated bubbles for at least one month.

Conclusions:

  • The reported microfluidic strategy provides a robust method for creating stable microbubbles.
  • The protein-polysaccharide shell ensures bubble integrity and longevity.
  • This technique offers potential for applications requiring stable micro-disperse systems.