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Updated: Jun 1, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Self-complementary nucleoside-thiophene hybrid systems: synthesis and supramolecular organization
Maria Luisa Navacchia1, Laura Favaretto, Emanuele Treossi
1Consiglio Nazionale Ricerche, Istituto per la Sintesi Organica e la Fotoreattività (ISOF), via Gobetti, 101, I-40129, Bologna, Italy. m.l.navacchia@isof.cnr.it.
Abstract:
Versatile synthetic methods towards a variety of thiophene-nucleobase hybrid systems are reported. Adenine- and thymine-based modified nucleosides characterized by a bithiophene unit linked to the C5' or C8 position through an ethylenamino or an ethylensulfanyl bridge were synthesized and successfully polymerized in the presence of FeCl(3) . The self-organization properties of the pure polymers as well as their mixtures - with complementary nucleobases - were investigated by means of optical microscopy and AFM in cast film showing complex supramolecular structures resulting from the interplay of multiple intermolecular interactions.
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