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Updated: Jun 1, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
The advantages of in situ surfactant generation for miniemulsions
Ula El-Jaby1, Michael Cunningham, Timothy F L McKenna
1Department of Chemical Engineering, Queen's University, Kingston, Ontario, Canada; CNRS-LCPP/ CPE-LYON, BP 2007, Université Claude Bernard Lyon 1, Villeurbanne, 69616, France.
Abstract:
The stabilisation of miniemulsions using an in situ generated surfactant is presented. This surfactant, prepared from of a water-soluble base and an oil-soluble long chain acid was successfully used to create stable miniemulsions with up to 60 vol.-% organic phase. It is shown that the creation of a surface active species at the oil-water interface allowed stable miniemulsions to be generated more rapidly than when using conventional surfactant. In addition, polymerised miniemulsions exhibited less secondary nucleation when in situ surfactants were used.
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