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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Experimental approaches to microarray analysis of tumor samples.

Laura Lowe Furge¹, Michael B Winter, Jacob I Meyers

¹Department of Chemistry, Kalamazoo College, Kalamazoo, Michigan 49006-3295. lfurge@kzoo.edu.

Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology

|May 19, 2011

Summary

This study introduces microarray technology, a key tool for analyzing gene expression in biological samples. It provides educational questions to help students understand this essential technique in molecular biology and biochemistry courses.

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DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning

Published on: March 15, 2011

Area of Science:

Biochemistry
Molecular Biology
Genomics

Background:

High-density nucleic acid arrays, or microarrays, are crucial for comprehensive gene expression measurement.
Understanding molecular differences in clinical and research samples relies on microarray data.

Purpose of the Study:

To integrate microarray technology education into biochemistry and molecular biology curricula.
To provide educators with tools to engage students in learning about microarray applications.

Main Methods:

The article offers preparatory questions for students.
Problem-solving questions are included to deepen comprehension.
These resources are designed for use with existing course materials.

Main Results:

Engaging students in understanding microarray technologies.
Facilitating the learning of gene expression analysis techniques.
Preparing modern scientists with essential molecular biology skills.

Conclusions:

Microarray technology is fundamental for modern biological research.
Educational integration of microarrays is essential for training scientists.
The provided questions support effective student learning in this field.