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A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

[Independent predictors of deep vein thrombosis (results of prospective 18 months study)]

N M Vorob'eva, E P Panchenko, A B Dobrovol'skiĭ

    Kardiologiia
    |May 20, 2011
    PubMed

    Insights

    Recurrent deep vein thrombosis (DVT) is predicted by elevated D-dimer levels, a specific gene variant, and inconsistent anticoagulant therapy levels. These factors help identify patients at higher risk for DVT recurrence.

    Area of Science:

    • Cardiology
    • Hematology
    • Genetics

    Background:

    • Deep vein thrombosis (DVT) and pulmonary embolism (PE) are significant causes of morbidity and mortality.
    • Anticoagulant therapy is the cornerstone of treatment, but recurrence remains a concern.
    • Identifying predictors of recurrence is crucial for optimizing patient management.

    Purpose of the Study:

    • To identify independent predictors of recurrent DVT and PE in patients treated with anticoagulants.
    • To evaluate the association of various demographic, clinical, genetic, and laboratory parameters with recurrence risk.

    Main Methods:

    • Prospective follow-up of 90 patients with DVT and/or PE for 18 months.
    • Analysis of 165 parameters including demographic, anthropometric, clinical, genetic, instrumental, and laboratory data.
    • Multifactorial regression analysis to determine independent predictors of recurrence.

    Main Results:

    • The recurrence rate of DVT was 16.7% during the 18-month follow-up; no PE recurrences were observed.
    • Elevated D-dimer levels after one month of anticoagulant therapy were a significant predictor (RR 8.1).
    • Homozygosity for the C249T polymorphism in the beta-fibrinogen gene (RR 8.4) and a lower percentage of time within the therapeutic INR range (RR 0.94) were also independent predictors of DVT recurrence.

    Conclusions:

    • Elevated D-dimer, specific genetic predisposition (beta-fibrinogen C249T homozygosity), and suboptimal anticoagulation control are key predictors of recurrent DVT.
    • These findings can aid in risk stratification and personalized treatment strategies for patients with DVT.

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