Metabolic syndrome with or without diabetes contributes to left ventricular diastolic dysfunction
Wilfried Dinh1, Mark Lankisch, Werner Nickl
1Institute for Heart and Circulation Research, University Witten/Herdecke, Germany.
Acta Cardiologica
|May 20, 2011
Summary
Metabolic syndrome (MetS) significantly increases the prevalence and severity of left ventricular diastolic dysfunction (LVDD), especially when combined with diabetes. Early intervention for MetS patients with LVDD is crucial for preventing heart failure.
Area of Science:
- Cardiology
- Metabolic Disorders
- Diabetology
Background:
- Left ventricular diastolic dysfunction (LVDD) precedes diabetic cardiomyopathy.
- Metabolic syndrome (MetS) elevates cardiovascular risk.
- Glucose metabolism disturbances are linked to cardiovascular issues.
Purpose of the Study:
- To assess the association between LVDD, MetS, and glucose metabolism.
- To investigate LVDD in relation to MetS criteria and oral glucose tolerance testing (oGTT).
Main Methods:
- Evaluated LVDD in 166 subjects with preserved ejection fraction.
- Diagnosed MetS using NCEP-ATP III criteria.
- Assessed LVDD severity and performed oGTT as needed.
Main Results:
- LVDD prevalence was 68% in MetS patients vs. 19% without MetS (P < 0.001).
- Severe LVDD was more common in MetS (34% vs. 15%, P = 0.001).
- MetS patients showed reduced early diastolic tissue relaxation velocity (E') and higher E/E' ratio.
Conclusions:
- MetS is strongly associated with increased LVDD prevalence and severity.
- Coexisting diabetes exacerbates LVDD in MetS patients.
- MetS patients with LVDD are a target for early heart failure prevention.
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