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Related Concept Videos

Cardiac Action Potential01:30

Cardiac Action Potential

Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
Correlation between ECG and Cardiac Cycle01:25

Correlation between ECG and Cardiac Cycle

The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...

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Related Experiment Video

Updated: Jun 1, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Electrical remodelling in cardiac resynchronization therapy: decrease in intrinsic QRS duration.

Karl Mischke1, Christian Knackstedt, Kerstin Fache

  • 1Départment of Cardiology, Pneumatology and Angiology, RWTH Aachen University, Germany; kmischke@ukaachen.de

Acta Cardiologica
|May 20, 2011
PubMed
Summary
This summary is machine-generated.

Cardiac resynchronization therapy (CRT) reduces intrinsic QRS duration in patients with congestive heart failure (CHF). This electrical remodeling indicates CRT

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Related Experiment Videos

Last Updated: Jun 1, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

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Published on: December 11, 2017

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Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices
09:35

Preclinical Cardiac Electrophysiology Assessment by Dual Voltage and Calcium Optical Mapping of Human Organotypic Cardiac Slices

Published on: June 16, 2020

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Management

Background:

  • Cardiac resynchronization therapy (CRT) is a treatment for congestive heart failure (CHF) and left bundle-branch block.
  • While structural remodeling from CRT is known, electrical remodeling effects were less understood.

Purpose of the Study:

  • To investigate if CRT induces electrical remodeling by decreasing intrinsic QRS duration.
  • To assess the impact of CRT response and underlying heart disease on QRS duration changes.

Main Methods:

  • 38 CHF patients (ejection fraction 26±7%) received CRT.
  • Echocardiography and ECGs were performed pre-CRT and at 6 and 12 months.
  • Patients were classified as responders based on ejection fraction and NYHA class improvements.

Main Results:

  • Ejection fraction improved significantly post-CRT (36% at 6 months, 40% at 12 months).
  • Intrinsic QRS duration decreased from 171±18 ms to 161±25 ms at 12 months (P=0.002).
  • Responders showed a significant QRS duration decrease, unlike non-responders, though not statistically significant in variance analysis.

Conclusions:

  • CRT induces electrical remodeling, leading to a reduction in intrinsic QRS duration.
  • This suggests CRT impacts the heart's electrical properties beyond structural changes.