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Increased serum myeloid-related protein 8/14 level is associated with atherosclerosis in type 2 diabetic patients

Wen Hui Peng1, Wei Xia Jian, Hai Ling Li

  • 1Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. pwenhui@yahoo.com.cn

Cardiovascular Diabetology
|May 20, 2011
PubMed
Abstract

Insights

Myeloid-related protein 8/14 (MRP8/14) is elevated in diabetic patients with coronary artery disease (CAD) and correlates with CAD severity and carotid intima-media thickness (IMT). This suggests MRP8/14 is a potential biomarker for cardiovascular risk in diabetes.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Diabetology

Background:

  • Myeloid-related protein 8/14 (MRP8/14) is a heterodimer involved in vascular inflammation and acute coronary syndrome.
  • MRP8/14's role in diabetic cardiovascular complications is not fully understood.

Purpose of the Study:

  • To investigate the correlation between serum MRP8/14, hsCRP, and esRAGE levels and the presence/severity of coronary artery disease (CAD) in diabetic patients.
  • To assess the association of these markers with carotid intima-media thickness (IMT) in diabetic and non-diabetic individuals without CAD.

Main Methods:

  • Serum levels of MRP8/14, esRAGE, and hsCRP were measured in 375 diabetic patients.
  • Patients were categorized based on the presence and severity of CAD.
  • Associations with IMT were examined in diabetic and non-diabetic groups without CAD.

Main Results:

  • Serum MRP8/14 levels were significantly higher in patients with CAD compared to those without (9.7 vs. 8.2 ug/ml, P < 0.001).
  • MRP8/14 positively correlated with CAD severity (r = 0.16, P = 0.026) and IMT in non-CAD patients with (r = 0.30, P < 0.001) and without diabetes (r = 0.26, P = 0.015).
  • hsCRP demonstrated a higher diagnostic performance for CAD than MRP8/14 or esRAGE.

Conclusions:

  • Diabetic patients with CAD exhibit elevated plasma MRP8/14 levels.
  • MRP8/14 is positively correlated with CAD severity and carotid IMT in patients without clinically overt CAD.
  • MRP8/14 may serve as a valuable biomarker for assessing cardiovascular risk in diabetic populations.

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