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F-cell levels are altered with erythrocyte density in sickle cell disease

Sumanta Basu1, Bisnu Prasad Dash, Dilip Kumar Patel

  • 1Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, India.

Blood Cells, Molecules & Diseases
|May 20, 2011
PubMed

Lighter cells from density fractionated erythrocytes of sickle cell disease (SCD) patients carry higher amount of externalized phosphatidylserine (PS) and cell surface glycophorins compared to the denser counterparts. Further analysis also revealed that the denser cells contained higher levels of fetal hemoglobin (HbF) compared to the lighter cells, supported by the presence of larger number of F-cells in these populations. In this report, we have found direct evidence on the higher survival of the HbF rich erythrocytes in SCD.

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