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Related Experiment Video

Updated: Jun 1, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Pre-eclampsia in low and middle income countries.

Tabassum Firoz¹, Harshad Sanghvi, Mario Merialdi

¹University of British Columbia, Department of Medicine, Women's Health Centre, Vancouver, Canada. tabassum@interchange.ubc.ca

Best Practice & Research. Clinical Obstetrics & Gynaecology

|May 20, 2011

Summary

Pre-eclampsia and eclampsia cause many global maternal deaths, especially in low- and middle-income countries (LMIC). Community health workers can improve timely care and reduce mortality from these conditions.

Related Experiment Videos

Last Updated: Jun 1, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Area of Science:

Obstetrics and Gynecology
Global Health
Maternal Health

Background:

Pre-eclampsia and eclampsia are major global causes of maternal and perinatal mortality.
Most deaths in low- and middle-income countries (LMIC) occur within the community, necessitating localized interventions.
Challenges in LMIC include resource limitations and healthcare worker shortages, impacting timely care for pre-eclampsia.

Purpose of the Study:

To highlight the critical need for community-level interventions for pre-eclampsia in LMIC.
To explore strategies like task shifting to address healthcare worker shortages.
To emphasize universal prevention and the need for accessible diagnostic tools.

Main Methods:

Review of existing literature on pre-eclampsia management in resource-limited settings.
Analysis of barriers to care, including delays in triage, transport, and treatment.
Discussion of potential solutions such as task shifting and affordable diagnostic tools.

Main Results:

Three primary delays (triage, transport, treatment) contribute significantly to maternal mortality from pre-eclampsia.
Task shifting, particularly utilizing community health workers, is a viable strategy to improve timely care.
Limited resources hinder accurate blood pressure and proteinuria measurement, necessitating affordable detection tools.

Conclusions:

Community-based interventions and task shifting are crucial for managing pre-eclampsia in LMIC.
Universal prevention strategies and accessible diagnostic tools are essential.
Addressing barriers to magnesium sulfate utilization is vital for eclampsia prevention and treatment.