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Updated: Jun 1, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Published on: June 6, 2017

Downstream of human NDR kinases: impacting on c-myc and p21 protein stability to control cell cycle progression

Hauke Cornils1, Reto S Kohler, Alexander Hergovich

  • 1Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

Cell Cycle (Georgetown, Tex.)
|May 20, 2011
PubMed

Insights

NDR kinases regulate cell division and tumor suppression. New findings reveal NDR1/2

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Oncology

Background:

  • The NDR/LATS kinase family (NDR1/2, LATS1/2) is conserved across species.
  • These kinases are involved in cell division, morphology, apoptosis, and tumor suppression.
  • LATS1/2 are key components of the HIPPO tumor suppressor pathway, regulating YAP/TAZ.
  • NDR1/2 are implicated in an extended HIPPO pathway, controlling centrosome duplication and mitosis.

Purpose of the Study:

  • To discuss novel cell cycle functions of NDR kinases.
  • To explore the role of NDR1/2 in G1/S transition.
  • To explain the opposing roles of NDR kinases in normal and tumor biology.

Main Methods:

  • Literature review and discussion of recent findings.
  • Analysis of the MST3-NDR1/2 signaling axis.
  • Examination of NDR kinase regulation of c-myc and p21.

Main Results:

  • NDR1/2 control G1/S transition downstream of MST3.
  • The MST3-NDR1/2 axis promotes cell cycle progression by stabilizing c-myc and inhibiting p21.
  • This suggests a potential pro-tumorigenic role for NDR kinases.

Conclusions:

  • NDR kinases exhibit novel cell cycle regulatory functions.
  • The dual roles of NDR kinases in normal and tumor biology warrant further investigation.
  • Understanding these functions is crucial for cancer research and therapeutic development.

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