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The phenotype standardization project: improving pharmacogenetic studies of serious adverse drug reactions
M Pirmohamed1, G P Aithal, E Behr
1Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK. munirp@liv.ac.uk
Abstract:
The ability to predict the risk for serious drug-induced adverse reactions first requires a large patient database for characterization and validation of genetic markers. The Phenotype Standardization Project (PSP) was initiated to standardize phenotypic definitions, thereby facilitating much-needed recruitment without sacrificing the reliability of patient classification. Three phenotypes have been considered in this initial phase: drug-induced liver injury, drug-induced skin injury, and drug-induced torsade de pointes.
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