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Updated: Jun 1, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
Treatment of hepatocellular carcinoma associated with extrahepatic primary cancer
Abstract:
Association of extrahepatic primary cancers (EPC) were studied in 533 consecutive hepatocellular carcinoma (HCC) cases. EPCs were found in 30 cases (5.6%). Three patients had two EPCs. The most frequent sites of EPC were the stomach (n=10, 30.3%), the colon (n=8, 24.2%), otolarynx (n=5, 15.2%), and the lung (n=2, 6.1%). Twenty-nine of 33 EPCs were treated by resection. EPCs did not affect the survival rate, however, the survival of the 20 patients who underwent resection of HCC was better than the 10 patients who did not. Liver cirrhosis was present in 8 of the 30 cases. Advanced stages of HCC were more frequently seen (P<0.05) in cases without cirrhosis.
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