Related Experiment Video
Updated: Jun 1, 2026
06:51
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
Collagen markers during anticancer therapy for lung cancer
Oncology Reports
|May 20, 2011
Summary
Collagen markers, aminoterminal propeptide of type IIE collagen (PIIIP) and 7-S collagen, are elevated in lung cancer. These markers may help predict patient response to chemotherapy.
Area of Science:
- Biochemistry
- Oncology
- Biomarkers
Background:
- Collagen metabolism markers, including PIIIP and 7-S collagen, are increasingly recognized for their association with cancer malignancy and disease progression.
- Elevated levels of these markers have been observed in various cancers, suggesting a role in tumor behavior.
Purpose of the Study:
- To evaluate serum concentrations of PIIIP and 7-S collagen in lung cancer patients.
- To correlate these collagen markers with clinical disease progression and response to chemotherapy.
Main Methods:
- Serum samples were collected from 48 lung cancer patients and compared to controls.
- Sixteen patients received cisplatin-based chemotherapy.
- Concentrations of PIIIP and 7-S collagen were measured and analyzed.
Main Results:
- Serum PIIIP and 7-S collagen levels were significantly higher in lung cancer patients compared to controls.
- In patients responding to chemotherapy, collagen markers showed a tendency to decrease.
- Non-responder patients exhibited a significant increase in collagen markers post-chemotherapy.
Conclusions:
- Elevated serum PIIIP and 7-S collagen are indicative of lung cancer.
- These collagen markers show potential for early assessment of tumor response to chemotherapy in lung cancer patients.
