Stimulatory effects of amphetamine on the development of Walker-256 carcinoma lung metastases in rats

Experiments were performed in order to evaluate the effects of amphetamine (0.4 mg/kg/day) on the development of lung metastases in rats injected i.v. with 10(4) Walker 256 (W-256) carcinosarcoma cells, The number of metastatic nodules on the surface of the lungs, as well as the percentage-area of metastases in the frontal section through pulmonary hilus were increased in rats injected with amphetamine in comparison with those injected with placebo. Survival periods were also assessed and amphetamine was found to increase the lethality of rats.