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Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
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Related Experiment Video

Updated: Jun 1, 2026

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
09:49

Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization

Published on: December 2, 2013

Intra-arterial induction chemotherapy.

F Stephens

    Oncology Reports
    |May 20, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Regional chemotherapy, once unsatisfactory for recurrent cancers, now offers effective, safe treatment options. Modern techniques address past limitations, highlighting its important role in comprehensive cancer care.

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    Published on: September 20, 2020

    Area of Science:

    • Oncology
    • Surgical Oncology
    • Pharmacology

    Background:

    • Intra-arterial chemotherapy was initially used for regional cancer problems but yielded poor results due to treating poorly vascularized, recurrent cancers.
    • This led to the intra-arterial approach falling into disrepute, with continued use often met with criticism and skepticism.

    Purpose of the Study:

    • To review the historical context and current understanding of regional chemotherapy techniques.
    • To address valid and invalid objections to the use of regional chemotherapy.
    • To highlight the potential of modern regional chemotherapy, particularly as induction treatment.

    Main Methods:

    • Historical review of regional chemotherapy applications and outcomes.
    • Analysis of reasons for past treatment failures.
    • Evaluation of current techniques and their efficacy.
    • Discussion of existing criticisms and their validity.

    Main Results:

    • Reasons for historical poor outcomes are now understood.
    • Effective and safe regional chemotherapy techniques have been developed.
    • Modern regional chemotherapy, especially as induction therapy, has a significant role in cancer treatment.

    Conclusions:

    • Despite past failures and ongoing skepticism, modern regional chemotherapy techniques are effective and safe.
    • Valid objections exist, primarily concerning resources and expertise, but many criticisms stem from outdated information or resistance to change.
    • Regional chemotherapy, when appropriately applied, is a valuable component of a comprehensive oncology therapeutic service.